Top aptamer papers on therapeutics — updated daily

Highest-scoring papers · 高分论文

1. abcFISH enables multiplexed, single-molecule visualization of circular RNA spatial heterogeneity

   Nature methods · IF 36.1 · 2026-11-05 · 5 citations · score 32.9

   Understanding the subcellular localization of RNAs is critical for their functions, but visualizing circular RNAs (circRNAs) has been hindered by their sequence overlap with linear counterparts. Here we developed amplicon-based circRNA fluorescence in situ hybridization (abcFISH), which uses an optimized…

2. Aptamer-mediated multivalent endogenous ADAR1 recruitment for highly efficient RNA editing

   Nature methods · IF 36.1 · 2026-10-28 · 0 citations · score 13.7

   Adenosine-to-inosine RNA editing mediated by endogenous ADAR enzymes represents a promising therapeutic strategy because it can correct mutations at the transcript level without inducing permanent changes to the genome. However, existing systems face challenges, particularly the limited editing efficiency, which…

3. From recognition to delivery: nucleic acid aptamers in miRNA-related diagnosis and therapy of hepatocellular carcinoma

   Frontiers in Pharmacology · IF 5.6 · 2026-11-04 · 0 citations · score 12.7

   Hepatocellular carcinoma (HCC), the most common primary malignant liver tumour, remains a major clinical challenge because of its low early diagnosis rate and high post-treatment recurrence. MicroRNAs (miRNAs) play key regulatory roles in HCC development and progression and are potential liquid biopsy biomarkers and…

4. Aptamer-modified magnetic chitosan nanocomposites for rapid and targeted decontamination of aflatoxin B(1) in medicine-food homologous decoctions

   Mikrochimica acta · IF 5.4 · 2026-11-04 · 0 citations · score 12.6

   A novel aptamer-functionalized core-shell magnetic chitosan adsorbent (Fe₃O₄@CS@apt) was developed for the selective removal of a flatoxin B1 (AFB1). The material was synthesized via emulsification cross-linking followed by EDC/sulfo-NHS-mediated aptamer conjugation. Characterization confirmed the core-shell structure…

5. A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples

   Analytica chimica acta · IF 5.4 · 2026-10-22 · 1 citation · score 12.3

   To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of…

6. Expanding synthetic lethality through computationally designed aptamers

   Molecular Therapy — Nucleic Acids · IF 8.8 · 2026-10-31 · 0 citations · score 12.1

   Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic…

7. NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis

   Molecular pharmaceutics · IF 5.5 · 2026-11-02 · 0 citations · score 12.0

   Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform,…

8. Amplifying the invisible: Liquid crystal-hydrogel microcavities decode trace Hg ions and aflatoxin B1

   Journal of hazardous materials · IF 14.0 · 2026-10-28 · 0 citations · score 12.0

   Chinese herbal medicines (CHMs) have been applied to the prevention and treatment of numerous diseases. Ensuring the safety and pharmacological efficacy of CHMs demands precise detection of trace heavy metal ions and toxins, especially Hg and aflatoxin B1 (AFB1). However, due to subtle chemical signals, current…

9. Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

   Angewandte Chemie · IF 16.1 · 2026-10-27 · 0 citations · score 11.9

   ABSTRACT N1‐methylpseudouridine ( m Ψ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional…

10. Adaptation of a Fluorogenic RNA to N1-Methylpseudouridine Nucleoside Chemistry

    Angewandte Chemie (International ed. in English) · IF 16.1 · 2026-10-27 · 0 citations · score 11.9

    N1-methylpseudouridine (mΨ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional non-coding RNAs…

11. Beyond Static Architectures: Responsive Tetrahedral Framework Nucleic Acids for Precise Theranostics

    ACS nano · IF 15.8 · 2026-10-27 · 0 citations · score 11.8

    Precise theranostics requires spatiotemporal control and high specificity to adapt to complex physiological microenvironments. Tetrahedral framework nucleic acids (tFNA), classic 3D DNA nanostructures, offer distinct advantages such as atomic-level structural precision, intrinsic programmability, and excellent…

12. Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

    ACS nano · IF 15.8 · 2026-10-27 · 0 citations · score 11.8

    Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect…

13. A pH/miR-21 dual-responsive multifunctional DNA tetrahedron for targeted tumor imaging and synergistic chemo-gene therapy

    Talanta · IF 6.1 · 2026-10-30 · 0 citations · score 11.2

    Small interfering RNA (siRNA) presents promising prospects as a therapeutic agent; its clinical application is constrained by challenges such as inefficient delivery and off-target effects. This study developed a multifunctional DNA Tetrahedron (MDT) platform for synergistic delivery of siRNA and the chemotherapeutic…

14. Metal nanoparticle based biosensors for biomarker recognition: a review

    Analytical methods : advancing methods and applications · IF 3.0 · 2026-11-02 · 0 citations · score 11.0

    The determination of blood biomarkers in blood, tissues or other body fluids is crucial for many therapeutic and pathological interventions. Recently, metal nanoparticle-based biosensors have gained significant attention for the sensitive detection of such relevant biomarkers. This review summarizes recent advances in…

15. Exosome‐Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi–Chemo Therapy Through Cholesterol‐Free, Tumor‐Preferential Delivery

    Advanced Healthcare Materials · IF 10.0 · 2026-10-26 · 0 citations · score 10.7

    Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are…

16. Discovery of Two Potential and Novel Toll-like Receptor 7 Antagonists via Molecular Docking, Molecular Dynamics Simulation and In Vitro Biological Evaluation

    Molecules · IF 4.2 · 2026-10-29 · 0 citations · score 10.2

    Objective: Toll-like receptor 7 (TLR7) is an important pattern recognition receptor. It mainly participates in the recognition of single-stranded RNA and is closely related to various disease processes. In humans, the enormous potential of TLR7 antagonists in reducing inflammation and alleviating autoimmune damage has…

17. Fluorescence Quenching and Polarization Analysis of DNA Aptamers Binding to Green Fluorescent Protein: A Model System for Protein-Binding Aptamers and Assay Development

    Langmuir · IF 3.7 · 2026-10-29 · 0 citations · score 10.0

    Abstract Protein-binding aptamers are widely used in biosensing and therapeutics, yet reliable solution-phase methods for validating aptamer binding remain limited. Here, we establish green fluorescent protein (GFP) as a self-reporting benchmark system for homogeneous analysis of aptamer-protein interactions. A…

18. G4All: a database of experimentally confirmed G-quadruplex-forming sequences

    Nucleic acids research · IF 16.6 · 2026-10-21 · 0 citations · score 9.9

    G-quadruplexes (G4s) are non-canonical nucleic acid structures with critical roles in gene regulation, genomic stability, and disease, making them prime targets for therapeutic and biotechnological applications. However, the absence of a curated, centralized, experimentally validated repository of short (mostly…

19. Machine Learning-Enhanced Solid-State Nanopore Analysis for Single-Molecule Discrimination of Albumin and Aptamer-Bound Glycated Albumin Complexes

    ACS Omega · IF 4.1 · 2026-10-28 · 0 citations · score 9.8

    Abstract Discriminating glycated human serum albumin from unmodified albumin and aptamer-bound complexes at the single-molecule level is a sensing challenge unmet by conventional bulk analytical methods, which cannot resolve individual protein modification states. Here, we present a proof-of-concept solid-state…

20. Aptamer-Functionalized Pro-Photosensitizers for Targeted Elimination of Drug-Resistant Bacterial Biofilm Infection by Sequentially Activated Photodynamic-Antibiotic Therapy

    Small (Weinheim an der Bergstrasse, Germany) · IF 13.0 · 2026-10-22 · 0 citations · score 9.8

    Drug-resistant bacterial infections seriously threaten public health, and the formation of a biofilm barrier plays an important role. Drug-resistant biofilms are difficult to remove because the penetration and specificity of traditional antimicrobial drugs are poor, and the microenvironment in the inner layer of…