Top aptamer papers on infectious disease — updated daily
The 20 highest-scoring aptamer papers on infectious disease, ranked by the formula below and rebuilt every day. Drawn from 145 matching papers (out of 2972 in the aptamer corpus) published 2026-05-12 to 2026-11-04 across 102 journals.
按下方公式排序的 infectious disease 方向高分适配体论文，每日重建。取自语料中命中该主题的 145 篇（全库 2972 篇），发表于 2026-05-12 至 2026-11-04，涉及 102 个期刊。
Highest-scoring papers · 高分论文
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Dual DNA Nanomaterial-Regulated Homogeneous Immunoreaction-Enabled One-Step Electrochemical Analysis of Multiple Biomarkers in Clinical Samples
Abstract Homogeneous immunoassays offer a streamlined alternative to traditional heterogeneous methods by eliminating separation and washing steps. However, they are often hampered by low sensitivity, matrix interference, and limited multiplexing capability. Herein, we reported a dual DNA nanomaterial-based…
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Integrated Single-Step Duplex CRISPR-Based System for Point-of-Care Detection of Human Immunodeficiency Virus and Treponema pallidum Directly from Whole Blood
Abstract Acquired immunodeficiency syndrome (AIDS) and syphilis are two major sexually transmitted diseases that pose serious threats to public health, underscoring the urgent need for fast and sensitive diagnosis for human immunodeficiency virus (HIV) and Treponema pallidum (TP). Here, we developed a single-step…
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COMSOL-Based Impedance and Sensitivity Analysis of an Interdigitated Electrode Biosensor for Dengue NS1 Detection
Dengue remains a major global public health concern, highlighting the need for rapid and sensitive methods for the early detection of dengue virus biomarkers. In the present study, a finite element model for the detection of dengue nonstructural protein 1 (NS1) using an interdigitated electrode (IDE)-based…
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Aptamer-Functionalized Pro-Photosensitizers for Targeted Elimination of Drug-Resistant Bacterial Biofilm Infection by Sequentially Activated Photodynamic-Antibiotic Therapy
Drug-resistant bacterial infections seriously threaten public health, and the formation of a biofilm barrier plays an important role. Drug-resistant biofilms are difficult to remove because the penetration and specificity of traditional antimicrobial drugs are poor, and the microenvironment in the inner layer of…
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Structure-Guided Optimization of a LipL32-Targeting DNA Aptamer through Molecular Dynamics and Free-Energy Analysis
Accurate detection of leptospirosis requires high-affinity recognition of the conserved LipL32 biomarker. Although LipL32-targeting DNA aptamers have been identified through systematic evolution of ligands by exponential enrichment (SELEX), the molecular basis of their target recognition remains unclear, limiting…
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Dual-aptamer magnetic capture and electrochemical detection of influenza B and respiratory syncytial viruses in artificial saliva
Saliva is a promising non-invasive specimen for respiratory virus diagnostics but its biochemical complexity challenges direct interfacing with affinity-based biosensors. We report a dual-aptamer magnetic-capture electrochemical assay for detection of influenza B virus (IBV) and human respiratory syncytial virus…
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Dual-Format Plasmonic Biosensors for the Detection of SARS-CoV-2 and the Oxidative Stress Biomarker sNOX2-dp
Abstract The integrated surveillance, combining wastewater-based epidemiology (WBE) with clinical biomarker detection, is a game-changer approach to give a big-picture view of human health in large areas. In the present study, we introduce and evaluate 2 plasmonic biosensing architectures specifically designed for…
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Computationally Guided Cannabinoid Discovery for Antiviral and Anticancer Applications: Chemical Space, Molecular Modeling, and Artificial Intelligence
Cannabinoids represent a structurally diverse class of molecules with potential applications in antiviral and anticancer drug discovery. However, their conformational flexibility, polypharmacology, physicochemical limitations, and heterogeneous biological effects complicate the identification of therapeutically…
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A lifetime with RNA: John J. Rossi and the questions that science revisits
Dr. John J. Rossi's scientific career has unfolded alongside the transformation of RNA from a biological intermediary into a programmable therapeutic modality. Beginning with catalytic RNA and anti-HIV ribozymes, his work progressed through RNA interference, expressed siRNA and shRNA, combinatorial RNA gene therapy,…
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Aptamer-Based Fluorescent Assays for Detection of the Host-Response Viral Biomarker 3′-Deoxy-3′,4′-Didehydro-Cytidine
Abstract Improved viral diagnostics are urgently needed to strengthen pandemic preparedness and combat antimicrobial resistance, highlighting the importance of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), a host-derived, pan-viral biomarker that addresses key limitations of PCR-based diagnostics. Current methods for ddhC…
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A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing
Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR…
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CRISPR/Cas12-powered electrochemical biosensor for chikungunya virus DNA detection using gold-modified screen-printed carbon electrodes
Background and purpose: Chikungunya virus (CHIKV) remains a health concern because its symptoms overlap with dengue and Zika, often leading to misdiagnosis. Conventional diagnostic methods, including viral isolation, enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction…
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Aptamer-Targeted PLGA Nanoparticles for Biofilm-Directed Intra-articular Antibiotic Delivery in Prosthetic Joint Infection
Introduction: Prosthetic joint infection (PJI) is a severe complication of orthopedic surgery, driven by biofilm-forming bacteria such as Staphylococcus aureus. Conventional antibiotics are limited in penetrating biofilms or remaining localized at the infection site. We engineered a targeted nanocarrier system by…
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Aptamers for precision diagnosis and therapy for viral infections and parasitic neglected tropical diseases
Parasitic and viral pathogens impose a significant global health burden. Early, accurate, and affordable diagnostics remain scarce, as do therapeutics that provide a sterile cure. To address these burdens, aptamers have been proposed as potential alternatives. They offer enhanced stability through conformational…
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Rapid and sensitive on-chip microcapillary electrophoresis for discrete SARS-CoV-2 immunocomplex diagnostics
Rapid, sensitive, and quantitative molecular diagnostics remain in sustained demand, driving the development of miniaturized analytical platforms. Conventional rapid antigen tests rely on lateral-flow techniques, requiring capture and detection antibodies, gold nanoparticle labels, and precise binding kinetics to…
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Recognition–decision–execution: a new design principle for intelligent antimicrobial systems
The continued rise of antimicrobial resistance highlights fundamental limitations of prevailing antibacterial strategies, which remain largely dominated by continuous, non-directed killing. Although combination therapies and multifunctional materials are frequently described as synergistic, many reported effects…
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Strategies for biofilm disruption: Mechanisms, polymeric networks, mixed infections, and emerging biomaterials
Biofilms represent the predominant microbial lifestyle in clinical and environmental settings, where the extracellular polymeric substance (EPS) matrix provides structural integrity, metabolic cooperation, and pronounced antimicrobial tolerance. This matrix forms a dynamic macromolecular network of polysaccharides,…
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High-Throughput On-Chip Screening Enables Rapid Adaptation of DNA Aptamers to SARS-CoV-2 Evolution
Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10-12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to…
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Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1
A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes.…
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Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA
Functional DNA nanoassemblies (fDns) hold promise for biomedical and translational applications, but broader deployment is limited by manufacturing barriers that constrain scalability, reproducibility, and stability. Current biosynthetic approaches rely heavily on downstream enzymatic processing and purification,…
How this list is built · 这份榜单怎么来的
Sources. PubMed, OpenAlex and bioRxiv are polled daily for aptamer-related publications; records are de-duplicated by DOI.
Topic filter. A paper enters this list when its title or abstract matches any of: SARS-CoV-2, COVID*, influenza, HIV, HBV, HCV, tuberculosis, Mycobacterium, Ebola, Zika, Dengue, bacterial infect*, viral infect*, pathogen detect*, antimicrobial, antibiotic resist* (SQLite FTS5, case-insensitive, * is a prefix wildcard). A paper can belong to several topics.
Ranking. composite = 0.45×log(IF) + 0.35×log(citation velocity) + 0.10×social + 0.10×recency, scaled to 100. Citation velocity is citations per day since publication, so a recent paper accruing citations quickly can outrank an older one with a larger total. The recency term decays linearly to zero at 30 days, so anything older than a month is ranked on impact and citation velocity alone — this list therefore tilts towards recent work by design.
What this is not. The ranking is computed from metadata — journal impact factor, citation counts, recency — not from reading the papers. It is a triage aid for deciding what to read, not a quality judgement or a substitute for a systematic review. Impact factor is missing for some venues (preprints in particular) and those papers score lower than their content may deserve.
这份榜单由元数据算出——期刊影响因子、引用数、时效性——而不是通过阅读论文得到。它是决定「先读哪篇」的分诊工具，不是质量判断，也不能替代系统综述。部分来源（尤其预印本）没有影响因子，其得分会低于内容应得的水平。
Where these papers appear · 语料期刊分布
| Journal | Papers | IF |
|---|---|---|
| bioRxiv (Cold Spring Harbor Laboratory) | 10 | — |
| Zenodo (CERN European Organization for Nuclear Research) | 7 | — |
| ACS Sensors | 6 | 8.2 |
| ACS sensors | 4 | 8.2 |
| Analytical Chemistry | 3 | 6.7 |
| bioRxiv | 3 | — |
| ACS Nano | 2 | 15.8 |
| Biosensors & bioelectronics | 2 | 10.7 |
Daily archive · 每日归档（30 期）
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