Aptamer 学术简报 — infectious_disease — 2026-11-07

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 13 篇命中（aptamer 池 205 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.2] Dual DNA Nanomaterial-Regulated Homogeneous Immunoreaction-Enabled One-Step Electrochemical Analysis of Multiple Biomarkers in Clinical Samples

Abstract Homogeneous immunoassays offer a streamlined alternative to traditional heterogeneous methods by eliminating separation and washing steps. However, they are often hampered by low sensitivity, matrix interference, and limited multiplexing capability. Herein, we reported a dual DNA nanomaterial-based homogeneous electrochemical immunoassa...

#2 [13.3] Integrated Single-Step Duplex CRISPR-Based System for Point-of-Care Detection of Human Immunodeficiency Virus and Treponema pallidum Directly from Whole Blood

Abstract Acquired immunodeficiency syndrome (AIDS) and syphilis are two major sexually transmitted diseases that pose serious threats to public health, underscoring the urgent need for fast and sensitive diagnosis for human immunodeficiency virus (HIV) and Treponema pallidum (TP). Here, we developed a single-step duplex CRISPR assay that integra...

#3 [11.6] COMSOL-Based Impedance and Sensitivity Analysis of an Interdigitated Electrode Biosensor for Dengue NS1 Detection

Dengue remains a major global public health concern, highlighting the need for rapid and sensitive methods for the early detection of dengue virus biomarkers. In the present study, a finite element model for the detection of dengue nonstructural protein 1 (NS1) using an interdigitated electrode (IDE)-based impedimetric biosensor was developed in...

#4 [9.5] Structure-Guided Optimization of a LipL32-Targeting DNA Aptamer through Molecular Dynamics and Free-Energy Analysis.

Accurate detection of leptospirosis requires high-affinity recognition of the conserved LipL32 biomarker. Although LipL32-targeting DNA aptamers have been identified through systematic evolution of ligands by exponential enrichment (SELEX), the molecular basis of their target recognition remains unclear, limiting rational post-SELEX optimization...

#5 [9.2] Dual-aptamer magnetic capture and electrochemical detection of influenza B and respiratory syncytial viruses in artificial saliva.

Saliva is a promising non-invasive specimen for respiratory virus diagnostics but its biochemical complexity challenges direct interfacing with affinity-based biosensors. We report a dual-aptamer magnetic-capture electrochemical assay for detection of influenza B virus (IBV) and human respiratory syncytial virus (hRSV) in artificial saliva. For ...

#6 [7.7] Dual-Format Plasmonic Biosensors for the Detection of SARS-CoV-2 and the Oxidative Stress Biomarker sNOX2-dp

Abstract The integrated surveillance, combining wastewater-based epidemiology (WBE) with clinical biomarker detection, is a game-changer approach to give a big-picture view of human health in large areas. In the present study, we introduce and evaluate 2 plasmonic biosensing architectures specifically designed for detecting two analytical target...

#7 [6.7] Computationally Guided Cannabinoid Discovery for Antiviral and Anticancer Applications: Chemical Space, Molecular Modeling, and Artificial Intelligence

Cannabinoids represent a structurally diverse class of molecules with potential applications in antiviral and anticancer drug discovery. However, their conformational flexibility, polypharmacology, physicochemical limitations, and heterogeneous biological effects complicate the identification of therapeutically relevant candidates. This review e...

#8 [6.7] A lifetime with RNA: John J. Rossi and the questions that science revisits.

Dr. John J. Rossi's scientific career has unfolded alongside the transformation of RNA from a biological intermediary into a programmable therapeutic modality. Beginning with catalytic RNA and anti-HIV ribozymes, his work progressed through RNA interference, expressed siRNA and shRNA, combinatorial RNA gene therapy, and aptamer-guided delivery. ...

#9 [6.3] CRISPR/Cas12-powered electrochemical biosensor for chikungunya virus DNA detection using gold-modified screen-printed carbon electrodes

Background and purpose: Chikungunya virus (CHIKV) remains a health concern because its symptoms overlap with dengue and Zika, often leading to misdiagnosis. Conventional diagnostic methods, including viral isolation, enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR), are time-consuming, costly...

#10 [6.3] Aptamer-Targeted PLGA Nanoparticles for Biofilm-Directed Intra-articular Antibiotic Delivery in Prosthetic Joint Infection

Introduction: Prosthetic joint infection (PJI) is a severe complication of orthopedic surgery, driven by biofilm-forming bacteria such as Staphylococcus aureus. Conventional antibiotics are limited in penetrating biofilms or remaining localized at the infection site. We engineered a targeted nanocarrier system by conjugating DNA aptamers specifi...

Methodology