Top aptamer papers on cancer — updated daily

Highest-scoring papers · 高分论文

1. Single-Step Electrochemical Aptasensor for Melatonin Detection in Unprocessed Plasma

   Advanced science (Weinheim, Baden-Wurttemberg, Germany) · IF 14.3 · 2026-11-04 · 0 citations · score 14.3

   Melatonin is a clinically relevant biomarker for diagnosing circadian rhythm sleep disorders (CRSDs) and monitoring circadian disruption associated with cancer, metabolic and cardiovascular disease, and psychiatric disorders. This work reports the implementation of an electrochemical aptamer-based biosensor…

2. Dual DNA Nanomaterial-Regulated Homogeneous Immunoreaction-Enabled One-Step Electrochemical Analysis of Multiple Biomarkers in Clinical Samples

   ACS Nano · IF 15.8 · 2026-11-03 · 0 citations · score 14.2

   Abstract Homogeneous immunoassays offer a streamlined alternative to traditional heterogeneous methods by eliminating separation and washing steps. However, they are often hampered by low sensitivity, matrix interference, and limited multiplexing capability. Herein, we reported a dual DNA nanomaterial-based…

3. Visualizing Single-Cell Secretion with Electrochemiluminescence Imaging

   ACS nano · IF 15.8 · 2026-11-03 · 0 citations · score 14.2

   Secretory proteins encode cellular states not only through their abundance but also through their intracellular transport before being released. However, visualizing protein secretion behavior with molecular specificity and a low background remains challenging. Here, we report VEGF-responsive electrochemiluminescence…

4. From recognition to delivery: nucleic acid aptamers in miRNA-related diagnosis and therapy of hepatocellular carcinoma

   Frontiers in Pharmacology · IF 5.6 · 2026-11-04 · 0 citations · score 12.7

   Hepatocellular carcinoma (HCC), the most common primary malignant liver tumour, remains a major clinical challenge because of its low early diagnosis rate and high post-treatment recurrence. MicroRNAs (miRNAs) play key regulatory roles in HCC development and progression and are potential liquid biopsy biomarkers and…

5. Expanding synthetic lethality through computationally designed aptamers

   Molecular Therapy — Nucleic Acids · IF 8.8 · 2026-10-31 · 0 citations · score 12.1

   Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic…

6. NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis

   Molecular pharmaceutics · IF 5.5 · 2026-11-02 · 0 citations · score 12.0

   Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform,…

7. Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

   ACS nano · IF 15.8 · 2026-10-27 · 0 citations · score 11.8

   Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect…

8. A photoregulated DNA nanoflower for spatiotemporally controlled monitoring of adenosine triphosphate in living cells

   Analytica chimica acta · IF 5.4 · 2026-11-01 · 0 citations · score 11.6

   Visualization of adenosine triphosphate (ATP) dynamics in living cells is crucial for revealing metabolic abnormalities in tumors. Although DNA-based fluorescent probes show promise for biomolecular detection, their application in intracellular imaging faces several challenges, including insufficient cellular uptake…

9. A pH/miR-21 dual-responsive multifunctional DNA tetrahedron for targeted tumor imaging and synergistic chemo-gene therapy

   Talanta · IF 6.1 · 2026-10-30 · 0 citations · score 11.2

   Small interfering RNA (siRNA) presents promising prospects as a therapeutic agent; its clinical application is constrained by challenges such as inefficient delivery and off-target effects. This study developed a multifunctional DNA Tetrahedron (MDT) platform for synergistic delivery of siRNA and the chemotherapeutic…

10. Metal nanoparticle based biosensors for biomarker recognition: a review

    Analytical methods : advancing methods and applications · IF 3.0 · 2026-11-02 · 0 citations · score 11.0

    The determination of blood biomarkers in blood, tissues or other body fluids is crucial for many therapeutic and pathological interventions. Recently, metal nanoparticle-based biosensors have gained significant attention for the sensitive detection of such relevant biomarkers. This review summarizes recent advances in…

11. Exosome‐Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi–Chemo Therapy Through Cholesterol‐Free, Tumor‐Preferential Delivery

    Advanced Healthcare Materials · IF 10.0 · 2026-10-26 · 0 citations · score 10.7

    Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are…

12. IMAN: An Integrated Colorimetric Sensor for Direct Detection of PD-L1 on Extracellular Vesicles in Lung Cancer Diagnosis

    ACS applied materials & interfaces · IF 9.5 · 2026-10-26 · 0 citations · score 10.6

    Lung cancer is a leading cause of cancer mortality, yet early diagnosis remains difficult, highlighting the need for sensitive, noninvasive methods. Extracellular vesicles (EVs) and their surface proteins (e.g., PD-L1) are promising biomarkers; nevertheless, current EV detection requires time-consuming purification,…

13. CRISPR/Cas13a-Regulated SERS Biosensor Based on Plasmonic-Enhanced Magnetic Rods with Intensified Electromagnetic Field Generation for Breast Cancer Associated miRNA Detection

    ACS Sensors · IF 8.2 · 2026-10-26 · 0 citations · score 10.3

    Abstract Early and sensitive detection of breast cancer biomarkers is essential for improving patient prognosis, yet rapid and amplification-free analysis of low-abundance circulating miRNAs remains challenging. Herein, we report a CRISPR/Cas13a-regulated surface-enhanced Raman scattering (SERS) biosensor, termed the…

14. An Integrated Cascade-Amplified Microfluidic Biosensor for Reconfigurable Profiling of CRC-Associated Faecal Extracellular Vesicle Surface Proteins

    Small (Weinheim an der Bergstrasse, Germany) · IF 13.0 · 2026-10-23 · 0 citations · score 10.2

    Faecal extracellular vesicles (EVs) provide disease-relevant molecular information for non-invasive colorectal cancer (CRC) analysis. However, sensitive EV surface protein profiling remains challenging because low-abundance targets are obscured by heterogeneous vesicles and complex matrices. Here, an integrated…

15. Engineering aptamer-based therapeutics for precision cancer immunotherapy: from molecular targeting to clinical applications

    Frontiers in Pharmacology · IF 5.6 · 2026-10-26 · 0 citations · score 9.7

    Although cancer immunotherapy has revolutionized cancer therapy, the clinical efficacy of this approach is restricted due to tumor heterogeneity, immune escape, therapeutic resistance, poor tumor penetration, and toxic side effects. Short single-stranded DNA or RNA oligonucleotides, termed aptamers, have high affinity…

16. Engineering a Reconfigurable Transmembrane Receptor Enables Logic-Controlled Signal Translocation

    Journal of the American Chemical Society · IF 14.4 · 2026-10-21 · 0 citations · score 9.7

    Transmembrane receptors relay extracellular cues into intracellular responses through reconfigurable conformational changes, yet engineering synthetic systems that emulate receptor-like signal translocation with programmable control remains challenging. Here, we engineer a reconfigurable transmembrane receptor that…

17. A DNA Logic-Gated Cascade Amplification Biosensor for Highly Specific Electrochemical Detection of Circulating Tumor Cells

    ACS sensors · IF 8.2 · 2026-10-24 · 0 citations · score 9.7

    Circulating tumor cells (CTCs) are rare cancer-derived cells in peripheral blood, carrying vital information about tumor heterogeneity and progression. Their reliable detection remains challenging due to extreme rarity and high background interference. Herein, we report an electrochemical biosensor that integrates a…

18. Correlating Synthesis Conditions with Structural Evolution and Near-Infrared Emission in Glutathione-Capped Gold Nanoclusters

    ACS omega · IF 4.1 · 2026-10-27 · 0 citations · score 9.5

    Fluorescence imaging in the near-infrared (NIR) region has attracted increasing attention in biomedical research owing to its deep tissue penetration, reduced autofluorescence, and improved imaging contrast compared with visible-light imaging. Among NIR fluorescent probes, gold nanoclusters (AuNCs) are particularly…

19. A Bispecific Nanobridge Derived from Immunogenic Tumor Membranes Restores Dendritic Cell-T Cell Crosstalk for Enhanced Solid Tumor Immunotherapy

    ACS nano · IF 15.8 · 2026-10-20 · 0 citations · score 9.5

    In solid tumors, communication between dendritic cells (DCs) and T cells is impaired by poor immune infiltration and lack of physical contact, limiting current immunotherapies. Here, we develop a bispecific immune-bridging platform (NVMB) to address these limitations. NVMB consists of tumor cell membrane-derived…

20. Cascade DNA walker-driven photo-controlled CRISPR/Cas12a nanorobot enabling ultrasensitive one-pot detection of dual miRNAs in triple-negative breast cancer

    Talanta · IF 6.1 · 2026-10-25 · 0 citations · score 9.5