Aptamer 学术简报 — cancer — 2026-10-19

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 42 篇命中（aptamer 池 170 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.2] A dual-aptamer colorimetric sensor based on Cu-MOF@PtPdNPs for the highly sensitive detection of MUC1.

The abnormally high expression of MUC1 in various malignant tumors makes it a crucial biomarker for early cancer diagnosis. This study synthesized a Cu-MOF@PtPdNPs nanocomposite exhibiting robust peroxidase-like activity via an in-situ reduction method. By integrating this nanomaterial with a dual-aptamer recognition sandwich strategy, an effici...

#2 [14.6] Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targeting aptamer SL1 with early, recycling, and late endosomes following endocyt...

#3 [13.3] A Dual-Lock Activatable Fluorescent Probe Leveraging Tumor Metabolic and Enzymatic Features for Precision Imaging

Abstract Achieving highly sensitive and precise detection and imaging of cancer cells within the body is crucial for providing pathological information support in disease diagnosis and treatment. However, due to the existence of factors such as non-specific activation in local areas, membrane barriers, and the complexity of the intracellular env...

#4 [12.5] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells ...

#5 [12.5] Anchoring nanozymes on microneedles via nanotemplate sacrificial synthesis for glutathione detection.

Region-specific dysregulation of glutathione (GSH) reflects neuropsychiatric disorders and tumor progression. Microscale precision sampling combined with timely monitoring of GSH provides region-specific molecular information that may aid in disease diagnosis. To enable minimally invasive brain-compatible intraoperative detection of GSH within a...

#6 [12.3] Copper-Peptide Assemblies with Self-Driven Signal Release for Electrochemical Analysis of Exosomes

Abstract Multifunctional peptides have garnered considerable attention owing to their excellent biocompatibility and unique physicochemical properties. Herein, we report an electrochemical method for the sensitive detection of exosomes based on copper-peptide assemblies with a self-driven signal release approach. In the design, an engineered his...

#7 [12.3] A cell surface-targeted MNAzyme-aptamer system for highly sensitive and visual detection of cancer cells via nucleolin activation.

Cancer has become a major disease that seriously threatens human health and life worldwide. Cytological diagnosis serves as a cornerstone for clinical oncology. However, conventional cytomorphological evaluation and immunohistochemistry (IHC) remain time-consuming and inadequate for large-scale screening and rapid on-site precision diagnosis. Co...

#8 [12.3] Single Au@Pt bimetallic nanoparticle collision electrochemistry: Deep learning-assisted prediction and ultrasensitive matrix metalloproteinase-9 sensing.

Single-particle collision electrochemical technology (SPCE) shows significant potential for nanoscale sensing, owing to its high spatiotemporal resolution and label-free characteristics. Nonetheless, its application in real biological samples faces challenges such as limited selectivity and complications in quantitative signal analysis due to co...

#9 [11.7] Aptamer-Modified Extended-Gate Field-Effect Transistor Allows Direct Detection of Minute Cell Surface Charge for Early Diagnosis of Leukemia

Abstract A miniaturized and inexpensive biosensor should be developed for the early and rapid diagnosis of leukemia. In this study, we have demonstrated a direct electrical detection of leukemia cells such as CCRF-CEM using an extended-gate field-effect transistor (FET) sensor modified with the sgc8c aptamer. As a result, we found that the FET s...

#10 [11.5] Serum Proteomic Profiling by SomaScan Aptamer Array Identifies Candidate Predictive and Monitoring Biomarkers of Distant Recurrence in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) lacks a blood-based biomarker for predicting or monitoring distant recurrence. We profiled 39 serum samples from 38 women (10 healthy controls; 12 non-recurrent [NR]; eight diagnosis-timepoint samples from patients who later recurred [DR-DIG]; nine recurrence-timepoint samples [DR-REC]) using the SomaScan v5....

Methodology