Top aptamer papers on biosensors — updated daily

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1. Hierarchical triple-mode immunosensing of aflatoxin B1: From visual screening to precise confirmation

   Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · IF 4.6 · 2026-11-05 · 2 citations · score 25.8

   This work establishes a hierarchical triple-signal immunoassay based on a multifunctional nanocomposite of Prussian blue nanoparticle@carbon dot (PBNPs@CDs), aiming to address material complexity and system integration issues in multimodal sensing. PBNPs@CDs possess peroxidase-like activity, efficient photothermal…

2. A novel fluorescent aptasensor for sensitive and label-free detection of Di(2-ethylhexyl) phthalate based on catalytic hairpin assembly-assisted CRISPR/Cas9 and G-triplex

   Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · IF 4.6 · 2026-11-05 · 1 citation · score 23.2

   Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that poses significant risks to human health and ecosystems, making its sensitive, rapid, and reliable detection critically important for environmental monitoring and food safety assessment. CRISPR-Cas9, beyond its canonical site-specific endonuclease…

3. Unconventional DNA architecture in a dopamine–bound aptamer complex

   Nature Communications · IF 14.7 · 2026-10-24 · 8 citations · score 21.7

   Abstract Aptamers are oligonucleotides that have been selected to bind a particular target. Despite the growing popularity of functional DNA aptamers, there remains limited knowledge of their binding mechanisms, as few have been characterized at the atomic level. Here, we use NMR spectroscopy to obtain structural…

4. Near-Infrared Imaging of H(2)O(2) in Plants With Nanosensors Under Environmentally Changing Conditions

   Advanced materials (Deerfield Beach, Fla.) · IF 27.4 · 2026-10-30 · 1 citation · score 19.8

   Optical sensors are powerful tools to monitor biological systems. However, their practical deployment is often limited by environmental interferences such as autofluorescence, mechanical motion, and fluctuating illumination. These challenges are particularly pronounced in plants because they require and use light,…

5. A PMS-enhanced self-powered photoelectrochemical sensor based on dual-photoelectrode architecture for sensitive detection of carbofuran and acetamiprid

   Analytica chimica acta · IF 5.4 · 2026-11-01 · 1 citation · score 18.4

   A novel self-powered photoelectrochemical sensing platform was fabricated for the determination of acetamiprid and carbofuran. Donor-acceptor covalent organic frameworks were utilized as photoanode materials, while CuBr, with superior photochemical properties, served as the photocathode. The conjugated microporous…

6. Bimetallic synergy and aggregation-induced emission enhanced electrochemiluminescence aptasensor for detection of aflatoxin B1

   Analytica chimica acta · IF 5.4 · 2026-11-01 · 1 citation · score 18.4

   Aflatoxin B1 (AFB1), a highly carcinogenic mycotoxin widely contaminating agricultural products, poses a severe threat to food safety and human health, thereby necessitating the development of detection methods. Electrochemiluminescence (ECL) has emerged as an ideal analytical technique due to its near-zero background…

7. Re-selection of DNA aptamers for acetamiprid for light-up fluorescent detection

   Analytica chimica acta · IF 5.4 · 2026-11-01 · 1 citation · score 18.4

   Acetamiprid is currently the only member of second-generation neonicotinoid insecticides permitted for open-field use within the European Union following the ban of other neonicotinoids. Its potential environmental and health risks underscore the need for reliable detection methods. Although an acetamiprid aptamer was…

8. Dual-mode PEC-colorimetric aptasensor for sensitive aflatoxin B1 detection via a BiVO(4)/Ni(3)(HHTP)(2) heterojunction and PdAuCu nanoenzyme amplification

   Food research international (Ottawa, Ont.) · IF 7.0 · 2026-10-31 · 1 citation · score 18.1

   Rapid, sensitive, and accurate detection of aflatoxin B1 (AFB1) is essential for ensuring food safety. In this study, we developed a dual-mode photoelectrochemical-colorimetric (PEC-CL) aptasensor for AFB1 detection constructed from a BiVO4/Ni3(HHTP)2 type-II heterojunction integrated with a PdAuCu (PAC) ternary alloy…

9. Artificial neural network data fusion-mediated dual-mode sensor based on Fe(3)O(4)@PdIr for Salmonellatyphimurium detection in food

   Food research international (Ottawa, Ont.) · IF 7.0 · 2026-10-31 · 1 citation · score 18.1

   Salmonella Typhimurium (S. typhimurium) is a major foodborne pathogen that poses a serious threat to public health. In this study, a colorimetric/electrochemical dual-mode biosensor assisted by artificial neural network (ANN) was developed for the sensitive detection of S. typhimurium. Fe3O4@PdIr nanocomposites with…

10. Single-Step Electrochemical Aptasensor for Melatonin Detection in Unprocessed Plasma

    Advanced science (Weinheim, Baden-Wurttemberg, Germany) · IF 14.3 · 2026-11-04 · 0 citations · score 14.3

    Melatonin is a clinically relevant biomarker for diagnosing circadian rhythm sleep disorders (CRSDs) and monitoring circadian disruption associated with cancer, metabolic and cardiovascular disease, and psychiatric disorders. This work reports the implementation of an electrochemical aptamer-based biosensor…

11. Dual DNA Nanomaterial-Regulated Homogeneous Immunoreaction-Enabled One-Step Electrochemical Analysis of Multiple Biomarkers in Clinical Samples

    ACS Nano · IF 15.8 · 2026-11-03 · 0 citations · score 14.2

    Abstract Homogeneous immunoassays offer a streamlined alternative to traditional heterogeneous methods by eliminating separation and washing steps. However, they are often hampered by low sensitivity, matrix interference, and limited multiplexing capability. Herein, we reported a dual DNA nanomaterial-based…

12. Nano‐Optical Biomolecular Interaction Sensing Within Complex Media via Peptide Hybrid Ligand Conjugation

    Small · IF 13.0 · 2026-11-04 · 0 citations · score 14.2

    Protein-protein interactions (PPIs) govern most biological processes and are frequently altered in disease. However, in vitro characterization methods are often limited to binding affinities, specialized instrumentation, or are susceptible to extended-surface artifacts. Moreover, many remain incompatible with…

13. An Electrochemiluminescence Biosensing Platform Based on a Hydrogel-AAO Nanochannel Membrane for GFAP Detection

    ACS Sensors · IF 8.2 · 2026-11-05 · 0 citations · score 13.7

    Abstract Electrochemiluminescence (ECL) biosensors are widely used for ultrasensitive bioanalysis; however, their practical application is often limited by insufficient interface stability under complex detection conditions. Herein, an integrated hydrogel-AAO membrane (HAM) as a novel composite ion-exchange membrane…

14. Retraction notice to "Green-synthesized chitosan‑carbon dot nanocomposite as turn-on aptasensor for detection and quantification of Leishmania infantum parasite" [Int. J. Biol. Macromol. 270 (2024) 132483]

    International journal of biological macromolecules · IF 7.7 · 2026-11-05 · 0 citations · score 13.6

15. Integrated Single-Step Duplex CRISPR-Based System for Point-of-Care Detection of Human Immunodeficiency Virus and Treponema pallidum Directly from Whole Blood

    ACS Sensors · IF 8.2 · 2026-11-04 · 0 citations · score 13.3

    Abstract Acquired immunodeficiency syndrome (AIDS) and syphilis are two major sexually transmitted diseases that pose serious threats to public health, underscoring the urgent need for fast and sensitive diagnosis for human immunodeficiency virus (HIV) and Treponema pallidum (TP). Here, we developed a single-step…

16. Synergistic Spatial Confinement and Co-Reactant Acceleration Enable a Self-Enhanced Electrochemiluminescence-Electrochemical Dual-Mode Aptasensor for Acetamiprid

    Journal of agricultural and food chemistry · IF 5.7 · 2026-11-04 · 0 citations · score 12.7

    A long electron transfer distance and significant energy dissipation could cause low electrochemiluminescence (ECL) efficiency during mass-transfer reactions. To address this, a synergistic strategy based on spatial confinement and coreactant acceleration was proposed to enhance the ECL performance. Via an in situ…

17. From recognition to delivery: nucleic acid aptamers in miRNA-related diagnosis and therapy of hepatocellular carcinoma

    Frontiers in Pharmacology · IF 5.6 · 2026-11-04 · 0 citations · score 12.7

    Hepatocellular carcinoma (HCC), the most common primary malignant liver tumour, remains a major clinical challenge because of its low early diagnosis rate and high post-treatment recurrence. MicroRNAs (miRNAs) play key regulatory roles in HCC development and progression and are potential liquid biopsy biomarkers and…

18. MXene-based biosensors for pathogen detection: materials synthesis, sensing mechanisms, and analytical applications

    Mikrochimica acta · IF 5.4 · 2026-11-04 · 0 citations · score 12.6

    Rapid and accurate pathogen detection is essential for disease diagnosis, food safety, environmental monitoring, and public health surveillance. Conventional detection techniques, including culture-based assays, polymerase chain reaction (PCR), high-performance liquid chromatography (HPLC), and immunoassays, require…

19. A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples

    Analytica chimica acta · IF 5.4 · 2026-10-22 · 1 citation · score 12.3

    To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of…

20. A Pt@Z8P-based electrochemiluminescence aptasensor with T7 exonuclease-assisted amplification for ultrasensitive deoxynivalenol determination in cereals

    Food chemistry · IF 8.8 · 2026-10-31 · 0 citations · score 12.1

    Deoxynivalenol (DON) is among the most prevalent trichothecene mycotoxins in cereals and cereal-derived foods. Chronic low-level exposure to DON continues to pose health and economic risks. Herein, an electrochemiluminescence (ECL) aptasensor was developed from a dual-ligand ZIF-8-derived emitter (Pt@Z8P) integrated…