Top aptamer papers on neurodegeneration — updated daily

Highest-scoring papers · 高分论文

1. An Electrochemiluminescence Biosensing Platform Based on a Hydrogel-AAO Nanochannel Membrane for GFAP Detection

   ACS Sensors · IF 8.2 · 2026-11-05 · 0 citations · score 13.7

   Abstract Electrochemiluminescence (ECL) biosensors are widely used for ultrasensitive bioanalysis; however, their practical application is often limited by insufficient interface stability under complex detection conditions. Herein, an integrated hydrogel-AAO membrane (HAM) as a novel composite ion-exchange membrane…

2. Structure-Guided Design of an m1A Demethylation-Activated Aptamer for Live-Cell Monitoring of ALKBH3 Demethylase Activity

   Analytical Chemistry · IF 6.7 · 2026-10-27 · 0 citations · score 10.3

   Abstract AlkB homolog 3 (ALKBH3) is a demethylase that regulates nucleic acid modification dynamics, and dysregulated ALKBH3 activity is associated with various diseases, including cancers and neurodegenerative disorders. However, accurate monitoring of ALKBH3 demethylase activity in living cells remains challenging.…

3. CRISPR-Cas Assays for Protein Detection: Strategies and Clinical Applications

   Small methods · 2026-11-05 · 0 citations · score 9.3

   Measurement of protein biomarkers with high accuracy is critical for disease diagnostics and prognostic monitoring. However, conventional analytical platforms for protein detection suffer from insufficient sensitivity for low-abundance targets and require time-consuming, multi-step workflows. The CRISPR-Cas system is…

4. Author Correction: Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models

   Nature biotechnology · IF 33.1 · 2026-08-12 · 0 citations · score 6.9

5. Online aptamer-based solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry for the determination of Alzheimer's disease biomarkers

   Analytica chimica acta · IF 5.4 · 2026-10-01 · 1 citation · score 5.9

   BACKGROUND: Reliable quantification of amyloid-β (Aβ) peptides in biological fluids is of major clinical and research interest in Alzheimer disease context. Conventional offline extraction approaches often involve labor-intensive manual steps and high solvent consumption, limiting throughput routine applications,…

6. Mn-doped dual-emission CdZnSe/Mn:ZnS quantum dots for self-calibrated ratiometric sensing of Alzheimer's disease biomarker

   Analytica Chimica Acta · IF 5.4 · 2026-10-14 · 0 citations · score 5.6

7. Development of an RNA aptamer as a therapeutic agent for synucleinopathies

   Nature communications · IF 14.7 · 2026-07-15 · 0 citations · score 5.4

   The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the…

8. Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection

   Advanced science (Weinheim, Baden-Wurttemberg, Germany) · IF 14.3 · 2026-05-19 · 0 citations · score 5.3

   Colorectal cancer (CRC) poses a significant global health challenge, highlighting the need for better diagnostic tools and molecular targets. Compared to traditional antibodies, aptamers, which are single-stranded oligonucleotides with high affinity and low immunogenicity, offer an ideal platform for discovering novel…

9. Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

   Advanced Science · IF 14.3 · 2026-07-20 · 0 citations · score 5.3

   Ultrasensitive detection of low-abundance protein biomarkers is crucial for early disease diagnosis but remains challenging for the conventional barcode beads-based suspension chip platform due to the limited detection sensitivity. Here, we report a conceptually novel reaction termed "radical-mediated in situ…

10. Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42

    Talanta · IF 6.1 · 2026-08-15 · 1 citation · score 5.0

    Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath…

11. Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α

    Biosensors & bioelectronics · IF 10.7 · 2026-05-27 · 0 citations · score 4.8

    TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune…

12. A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light

    Biosensors & bioelectronics · IF 10.7 · 2026-06-03 · 0 citations · score 4.8

    Plasma neurofilament light chain (NfL) has been identified as a promising early-stage Alzheimer's disease (AD) biomarker, reflecting neuroaxonal degeneration at preclinical stages. However, its extremely low concentration in blood presents a major analytical challenge. Although single-molecule array (Simoa) assays…

13. Heterostructure nanozyme-synergistically modulated electrochemiluminescence/photoelectrochemical sensing platform for detection of Alzheimer's disease biomarkers in plasma samples

    Biosensors & bioelectronics · IF 10.7 · 2026-07-07 · 0 citations · score 4.8

    In this work, a PtPd/CeO2 heterostructure nanozyme-synergistically modulated ternary ZnS/CdS/Bi2Se3 electrochemiluminescence/photoelectrochemical (ECL/PEC) aptasensor was designed for simultaneous detection of amyloid-β peptides (Aβ1-40 and Aβ1-42), as the key plasma biomarkers of Alzheimer's disease (AD). Benefiting…

14. Ultrasensitive electrochemiluminescence aptasensor for Tau protein based on gold nanoparticle-modified perovskite nanocrystals

    Biosensors & bioelectronics · IF 10.7 · 2026-07-09 · 0 citations · score 4.8

    Early diagnosis for Alzheimer's disease (AD) is vital for effective therapeutic intervention and improved patient prognosis. In this work, we developed a highly sensitive electrochemiluminescence (ECL) aptasensor for detecting a key AD biomarker, Tau protein. An all-inorganic perovskite CsPbBr3 nanocrystals (NCs) were…

15. A bioelectronic interface for continuous neuroinflammation monitoring and neuromodulation in Parkinson's disease model

    Biosensors & bioelectronics · IF 10.7 · 2026-08-20 · 0 citations · score 4.8

    Neuroinflammation is increasingly recognized as a critical driver in the onset and progression of Parkinson's disease (PD), yet technologies capable of continuously tracking neuroinflammatory dynamics in vivo remain limited. Here, we report an implantable bioelectronic interface that integrates multiplexed aptamer…

16. Effects of a DNA Aptamer on α-Synuclein PFF–Induced Morphological Deficits in an in-vitro Model of Parkinson’s Disease

    Carleton undergraduate journal of science. · 2026-10-22 · 0 citations · score 4.7

    Parkinson’s disease (PD) is characterized by the accumulation and propagation of pathological α synuclein (αSyn) aggregates, which contribute to neuronal dysfunction and morphological alterations. Previous work by our group has shown that the α-Syn-1 DNA aptamer, when co administered with toxic αSyn Pre-Formed Fibrils…

17. Membrane-Coated DNA Nanoflowers Attenuate Cognitive Decline in Apolipoprotein E4 Mice

    ACS applied materials & interfaces · IF 9.5 · 2026-09-24 · 0 citations · score 4.6

    APOE4-driven mitochondrial dysfunction is one of the important primary drivers of cognitive decline in neurodegenerative diseases. However, achieving mitochondrial-targeted drug delivery in the nervous system requires overcoming multiple barriers, necessitating the development of a safer and more efficient…

18. Multicompartment Drug Monitoring Reveals Paired Brain-Liver Kinetics and Selective Central Nervous System Barrier Permeability in Rats

    ACS sensors · IF 8.2 · 2026-05-22 · 0 citations · score 4.3

    Characterizing drug distribution to target organs is of central importance to drug discovery, especially for compounds intended to reach the central nervous system (CNS). However, the current benchmark standard measurements, based on tissue homogenate, provide limited spatial and temporal resolution. Here, we use…

19. An electrochemiluminescence aptasensor based on resonance energy transfer between MXene/prussian blue analog hollow spheres and MXene@ZIF-67 for sensitive detection of Alzheimer's disease biomarkers

    Sensors and Actuators B Chemical · IF 8.0 · 2026-06-19 · 0 citations · score 4.3

20. Circular RNA in human brain: Systematic review of synaptic functions and disease associations

    International journal of biological macromolecules · IF 7.7 · 2026-06-01 · 0 citations · score 4.2

    Circular RNAs (circRNAs) are covalently closed, non-canonical transcripts, highly enriched in the mammalian brain and especially synaptic compartments. Generated via back-splicing of precursor mRNAs, their intrinsic stability and spatiotemporally regulated expression enable the modulating function for synaptic…