Aptamer 学术简报 — neurodegeneration — 2026-10-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 2 篇命中（aptamer 池 207 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [9.0] Mn-doped dual-emission CdZnSe/Mn:ZnS quantum dots for self-calibrated ratiometric sensing of Alzheimer's disease biomarker

• Journal: Analytica Chimica Acta (IF 5.4)
• Date: 2026-10-14 · Citations: 0
• Authors: Zhouqi Pan, Qianyu Wang, Qiumei Feng et al. (7 authors)
• DOI: 10.1016/j.aca.2026.346394
• Score components: IF 8.1 · recency 53.3

#2 [8.0] Effects of a DNA Aptamer on α-Synuclein PFF–Induced Morphological Deficits in an in-vitro Model of Parkinson’s Disease

• Journal: Carleton undergraduate journal of science. (IF ?)
• Date: 2026-10-22 · Citations: 0
• Authors: Daniel Minanengiyeofori, Kate Harris, Matthew R. Holahan
• DOI: 10.22215/cujs.v7i1.5866
• Score components: recency 80.0

Parkinson’s disease (PD) is characterized by the accumulation and propagation of pathological α synuclein (αSyn) aggregates, which contribute to neuronal dysfunction and morphological alterations. Previous work by our group has shown that the α-Syn-1 DNA aptamer, when co administered with toxic αSyn Pre-Formed Fibrils (PFFs), can halt the propag...

Methodology

• 数据源：PubMed (esearch + esummary), OpenAlex (concept C2776201186 + DOI 反查 citations), bioRxiv (preprints)
• 去重：按 DOI 跨源合并
• IF：硬编码 top 50 期刊 JCR 2024 IF（config.JOURNAL_IF）
• Citation velocity：OpenAlex cited_by_count / 发表天数
• Social：Reddit r/science + r/biotech + HN（DOI/title 关键词搜）
• 窗口：近 14 天发表；超出 30 天 recency_bonus = 0
• 每天：建议 8-9am 跑 python run.py collect && python run.py score && python run.py report