Aptamer 学术简报 — neurodegeneration — 2026-10-29

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 2 篇命中（aptamer 池 208 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.3] Structure-Guided Design of an m1A Demethylation-Activated Aptamer for Live-Cell Monitoring of ALKBH3 Demethylase Activity

Abstract AlkB homolog 3 (ALKBH3) is a demethylase that regulates nucleic acid modification dynamics, and dysregulated ALKBH3 activity is associated with various diseases, including cancers and neurodegenerative disorders. However, accurate monitoring of ALKBH3 demethylase activity in living cells remains challenging. Here, we report a structure-...

#2 [7.7] Effects of a DNA Aptamer on α-Synuclein PFF–Induced Morphological Deficits in an in-vitro Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by the accumulation and propagation of pathological α synuclein (αSyn) aggregates, which contribute to neuronal dysfunction and morphological alterations. Previous work by our group has shown that the α-Syn-1 DNA aptamer, when co administered with toxic αSyn Pre-Formed Fibrils (PFFs), can halt the propag...

Methodology