Aptamer 学术简报 — cancer — 2026-11-03

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 45 篇命中（aptamer 池 205 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.5] Expanding synthetic lethality through computationally designed aptamers

Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic RNAs, and direct modulation...

#2 [13.3] NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis.

Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform, SNs/FTC@Apt-P (SFTCP), constructed by in...

#3 [13.2] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

#4 [13.0] A photoregulated DNA nanoflower for spatiotemporally controlled monitoring of adenosine triphosphate in living cells.

Visualization of adenosine triphosphate (ATP) dynamics in living cells is crucial for revealing metabolic abnormalities in tumors. Although DNA-based fluorescent probes show promise for biomolecular detection, their application in intracellular imaging faces several challenges, including insufficient cellular uptake efficiency and nonspecific si...

#5 [12.5] A pH/miR-21 dual-responsive multifunctional DNA tetrahedron for targeted tumor imaging and synergistic chemo-gene therapy.

Small interfering RNA (siRNA) presents promising prospects as a therapeutic agent; its clinical application is constrained by challenges such as inefficient delivery and off-target effects. This study developed a multifunctional DNA Tetrahedron (MDT) platform for synergistic delivery of siRNA and the chemotherapeutic agent doxorubicin (DOX) to o...

#6 [12.4] Metal nanoparticle based biosensors for biomarker recognition: a review.

The determination of blood biomarkers in blood, tissues or other body fluids is crucial for many therapeutic and pathological interventions. Recently, metal nanoparticle-based biosensors have gained significant attention for the sensitive detection of such relevant biomarkers. This review summarizes recent advances in biosensors, based on copper...

#7 [12.0] Exosome‐Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi–Chemo Therapy Through Cholesterol‐Free, Tumor‐Preferential Delivery

Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are developed to embed three exosoma...

#8 [11.9] IMAN: An Integrated Colorimetric Sensor for Direct Detection of PD-L1 on Extracellular Vesicles in Lung Cancer Diagnosis.

Lung cancer is a leading cause of cancer mortality, yet early diagnosis remains difficult, highlighting the need for sensitive, noninvasive methods. Extracellular vesicles (EVs) and their surface proteins (e.g., PD-L1) are promising biomarkers; nevertheless, current EV detection requires time-consuming purification, sophisticated instrumentation...

#9 [11.7] CRISPR/Cas13a-Regulated SERS Biosensor Based on Plasmonic-Enhanced Magnetic Rods with Intensified Electromagnetic Field Generation for Breast Cancer Associated miRNA Detection

Abstract Early and sensitive detection of breast cancer biomarkers is essential for improving patient prognosis, yet rapid and amplification-free analysis of low-abundance circulating miRNAs remains challenging. Herein, we report a CRISPR/Cas13a-regulated surface-enhanced Raman scattering (SERS) biosensor, termed the CaRER sensor, for on-site de...

#10 [11.5] An Integrated Cascade-Amplified Microfluidic Biosensor for Reconfigurable Profiling of CRC-Associated Faecal Extracellular Vesicle Surface Proteins.

Faecal extracellular vesicles (EVs) provide disease-relevant molecular information for non-invasive colorectal cancer (CRC) analysis. However, sensitive EV surface protein profiling remains challenging because low-abundance targets are obscured by heterogeneous vesicles and complex matrices. Here, an integrated cascade-amplified microfluidic bio...

Methodology