Aptamer 学术简报 — cancer — 2026-10-25

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 37 篇命中（aptamer 池 177 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.3] A dual-aptamer colorimetric sensor based on Cu-MOF@PtPdNPs for the highly sensitive detection of MUC1.

The abnormally high expression of MUC1 in various malignant tumors makes it a crucial biomarker for early cancer diagnosis. This study synthesized a Cu-MOF@PtPdNPs nanocomposite exhibiting robust peroxidase-like activity via an in-situ reduction method. By integrating this nanomaterial with a dual-aptamer recognition sandwich strategy, an effici...

#2 [14.5] An Integrated Cascade-Amplified Microfluidic Biosensor for Reconfigurable Profiling of CRC-Associated Faecal Extracellular Vesicle Surface Proteins.

Faecal extracellular vesicles (EVs) provide disease-relevant molecular information for non-invasive colorectal cancer (CRC) analysis. However, sensitive EV surface protein profiling remains challenging because low-abundance targets are obscured by heterogeneous vesicles and complex matrices. Here, an integrated cascade-amplified microfluidic bio...

#3 [14.0] Engineering a Reconfigurable Transmembrane Receptor Enables Logic-Controlled Signal Translocation.

Transmembrane receptors relay extracellular cues into intracellular responses through reconfigurable conformational changes, yet engineering synthetic systems that emulate receptor-like signal translocation with programmable control remains challenging. Here, we engineer a reconfigurable transmembrane receptor that enables logic-controlled signa...

#4 [13.8] A Bispecific Nanobridge Derived from Immunogenic Tumor Membranes Restores Dendritic Cell-T Cell Crosstalk for Enhanced Solid Tumor Immunotherapy.

In solid tumors, communication between dendritic cells (DCs) and T cells is impaired by poor immune infiltration and lack of physical contact, limiting current immunotherapies. Here, we develop a bispecific immune-bridging platform (NVMB) to address these limitations. NVMB consists of tumor cell membrane-derived nanovesicles enriched with damage...

#5 [12.9] Digitally Printed Gold Nanoelectronics for Tap-to-Detect Electrochemical Biosensing and Chemical Sensing.

Printed electrochemical sensors offer a promising route toward decentralized diagnostics and environmental monitoring, but their practical use remains constrained by complex electrode fabrication and instrument-dependent readout. Here, we present a tap-to-detect sensing platform that couples digitally printed gold nanoparticle nanoelectronics wi...

#6 [12.6] Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targeting aptamer SL1 with early, recycling, and late endosomes following endocyt...

#7 [11.4] An Easy Oligonucleotide Platform for Rapid, Post-Isolation EV Modification: Dual-Function Uptake Control and Enhanced Targeting.

Extracellular vesicles (EVs) hold immense therapeutic potential, yet their clinical translation is hindered by nonspecific cellular uptake and the complexity and cost of surface engineering. Here, we present the EZON (Easy OligoNucleotide) EV modification platform, a cost-effective, post-isolation modification system that addresses both limitati...

#8 [11.3] A Dual-Lock Activatable Fluorescent Probe Leveraging Tumor Metabolic and Enzymatic Features for Precision Imaging

Abstract Achieving highly sensitive and precise detection and imaging of cancer cells within the body is crucial for providing pathological information support in disease diagnosis and treatment. However, due to the existence of factors such as non-specific activation in local areas, membrane barriers, and the complexity of the intracellular env...

#9 [10.5] Anchoring nanozymes on microneedles via nanotemplate sacrificial synthesis for glutathione detection.

Region-specific dysregulation of glutathione (GSH) reflects neuropsychiatric disorders and tumor progression. Microscale precision sampling combined with timely monitoring of GSH provides region-specific molecular information that may aid in disease diagnosis. To enable minimally invasive brain-compatible intraoperative detection of GSH within a...

#10 [10.3] Copper-Peptide Assemblies with Self-Driven Signal Release for Electrochemical Analysis of Exosomes

Abstract Multifunctional peptides have garnered considerable attention owing to their excellent biocompatibility and unique physicochemical properties. Herein, we report an electrochemical method for the sensitive detection of exosomes based on copper-peptide assemblies with a self-driven signal release approach. In the design, an engineered his...

Methodology