Aptamer 学术简报 — cancer — 2026-10-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 56 篇命中（aptamer 池 204 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.8] Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection.

The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the development of a high-performance ...

#2 [13.8] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells ...

#3 [13.8] Anchoring nanozymes on microneedles via nanotemplate sacrificial synthesis for glutathione detection.

Region-specific dysregulation of glutathione (GSH) reflects neuropsychiatric disorders and tumor progression. Microscale precision sampling combined with timely monitoring of GSH provides region-specific molecular information that may aid in disease diagnosis. To enable minimally invasive brain-compatible intraoperative detection of GSH within a...

#4 [13.6] A cell surface-targeted MNAzyme-aptamer system for highly sensitive and visual detection of cancer cells via nucleolin activation.

Cancer has become a major disease that seriously threatens human health and life worldwide. Cytological diagnosis serves as a cornerstone for clinical oncology. However, conventional cytomorphological evaluation and immunohistochemistry (IHC) remain time-consuming and inadequate for large-scale screening and rapid on-site precision diagnosis. Co...

#5 [13.6] Single Au@Pt bimetallic nanoparticle collision electrochemistry: Deep learning-assisted prediction and ultrasensitive matrix metalloproteinase-9 sensing.

Single-particle collision electrochemical technology (SPCE) shows significant potential for nanoscale sensing, owing to its high spatiotemporal resolution and label-free characteristics. Nonetheless, its application in real biological samples faces challenges such as limited selectivity and complications in quantitative signal analysis due to co...

#6 [13.4] A dual-aptamer colorimetric sensor based on Cu-MOF@PtPdNPs for the highly sensitive detection of MUC1.

The abnormally high expression of MUC1 in various malignant tumors makes it a crucial biomarker for early cancer diagnosis. This study synthesized a Cu-MOF@PtPdNPs nanocomposite exhibiting robust peroxidase-like activity via an in-situ reduction method. By integrating this nanomaterial with a dual-aptamer recognition sandwich strategy, an effici...

#7 [12.8] Serum Proteomic Profiling by SomaScan Aptamer Array Identifies Candidate Predictive and Monitoring Biomarkers of Distant Recurrence in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) lacks a blood-based biomarker for predicting or monitoring distant recurrence. We profiled 39 serum samples from 38 women (10 healthy controls; 12 non-recurrent [NR]; eight diagnosis-timepoint samples from patients who later recurred [DR-DIG]; nine recurrence-timepoint samples [DR-REC]) using the SomaScan v5....

#8 [12.1] Temperature-responsive PDDNFs@QDs integrating simplified isolation for efficient tumor-derived small extracellular vesicles analysis enables breast cancer diagnosis and subtyping.

Multiplexed small extracellular vesicles (sEVs) biomarker detection holds great promise for breast cancer diagnosis and subtyping; however, its clinical application is often hampered by the complex isolation and detection processes. Herein, we propose a temperature-responsive sensing platform (PDDNFs@QDs) utilizing poly(N-isopropylacrylamide) (P...

#9 [12.0] Bifunctional CuPt Nanoclusters and DSN-Mediated Target Recycling Enabled Dual-Mode OPECT/Colorimetric Biosensing for Ultrasensitive and Wide-Range Detection of miRNA-21

Abstract MicroRNA-21 (miRNA-21) is an important cancer biomarker that requires highly sensitive and reliable detection across a broad concentration range. Here, we report a dual-mode biosensing platform that integrates organic photoelectrochemical transistor (OPECT) amplification with nanozyme-assisted colorimetric transduction for ultrasensitiv...

#10 [12.0] Decoupled Signal Transduction via a Non-Copper Laccase Mimic for CRISPR-Based Electrochemical Detection of Hepatocellular Carcinoma

Abstract Laccase-mimicking nanozymes have been overwhelmingly copper-dependent, and largely confined to environmental contexts, with clinical translation remaining unrealized. Here, we depart from this paradigm by designing a non-copper nanozyme, Mn-Trp NR, assembled through manganese-tryptophan coordination. Spectroscopic and theoretical analys...

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