Aptamer 学术简报 — infectious_disease — 2026-10-13

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 8 篇命中（aptamer 池 214 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [11.7] Molecular Programming of CRISPR Diagnostics: From Target Recognition to Field Deployment

Abstract Rapid and accurate diagnostics are essential for controlling emerging infectious diseases and antimicrobial resistance, yet CRISPR assays with exceptional analytical sensitivity often remain difficult to translate into deployable tests. Existing reviews have commonly organized CRISPR diagnostics by Cas effector, biosensor format, or app...

#2 [10.0] Orthogonal Stimuli-Responsive Y-Shaped DNA Probe for Dual-Antibiotic Photoelectrochemical Detection

Abstract Simultaneously recognizing multiple targets and independently decoding their signals in food is critically demanded for safeguarding public health against antimicrobial resistance. Photoelectrochemical (PEC) sensors, promising for on-site detection, face a fundamental constraint: all targets generate unidimensional current signals at th...

#3 [9.5] A Colorimetric Approach to Identifying Single-Nucleotide Mutations Using Gold-Based Magnetic Nanoparticles

Detection of single-nucleotide mutations (SNPs) in the genome of infectious agents is one of the ways to identify their drug-resistant strains. Antibiotic-resistant strains of Mycobacterium tuberculosis (MTB) impede advances in the fight against the spread of tuberculosis. Diagnostic tools exist for both MTB itself and its drug-resistant strains...

#4 [9.0] Computationally Guided Design and Experimental Validation of ssDNA Aptamers Targeting the SARS-CoV-2 Spike Protein

Aptamer development has traditionally relied on iterative, labor-intensive experimental approaches. Recent advances in bioinformatics and computational power now enable the rational in silico design of high-affinity nucleic acid ligands, drastically reducing time and cost. Here, we present an integrated computational pipeline for designing ssDNA...

#5 [8.0] Multiplexed Aptamer-Based Proteomic Data Normalization (Adaptive Normalization by Maximum Likelihood) Significantly Influences Results in Critically Ill Patients.

BACKGROUND: Blood-based proteomics are employed in cohorts of patients with critical illness to provide biologic insights and improve diagnosis and risk stratification. Somalogic developed a multiplex aptamer-based platform (Somascan) with thousands of proteins assayed in a single plasma sample. Results are reported in 2 forms: (a) adaptive norm...

#6 [8.0] Achieving near single-molecule sensitivity in separation-free protein detection using engineered kinetic proofreading

Unlike nucleic acids, proteins cannot be directly amplified. Ultrasensitive detection must therefore couple efficient analyte-to-signal conversion with strong suppression of target-independent background. Consistently detecting ~100 molecules (below which Poisson sampling noise alone causes CV to exceed 10%) across protein targets in a format as...

#7 [6.0] Structure-Based Identification of Potential Toll-Like Receptor 3 Agonists for Anti-HBV Applications

Hepatitis B virus (HBV) infection remains a major global public health burden, primarily due to the persistence of covalently closed circular DNA (cccDNA) in infected hepatocytes. Toll-like receptor 3 (TLR3) has been suggested to be a promising therapeutic target, as its activation stimulates innate immune responses that facilitate cccDNA cleara...

Methodology