Aptamer 学术简报 — infectious_disease — 2026-10-27

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 10 篇命中（aptamer 池 197 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.5] Aptamer-Functionalized Pro-Photosensitizers for Targeted Elimination of Drug-Resistant Bacterial Biofilm Infection by Sequentially Activated Photodynamic-Antibiotic Therapy.

Drug-resistant bacterial infections seriously threaten public health, and the formation of a biofilm barrier plays an important role. Drug-resistant biofilms are difficult to remove because the penetration and specificity of traditional antimicrobial drugs are poor, and the microenvironment in the inner layer of biofilms is hypoxic. Herein, we d...

#2 [12.9] Dual-aptamer magnetic capture and electrochemical detection of influenza B and respiratory syncytial viruses in artificial saliva.

Saliva is a promising non-invasive specimen for respiratory virus diagnostics but its biochemical complexity challenges direct interfacing with affinity-based biosensors. We report a dual-aptamer magnetic-capture electrochemical assay for detection of influenza B virus (IBV) and human respiratory syncytial virus (hRSV) in artificial saliva. For ...

#3 [10.3] Aptamer-Based Fluorescent Assays for Detection of the Host-Response Viral Biomarker 3′-Deoxy-3′,4′-Didehydro-Cytidine

Abstract Improved viral diagnostics are urgently needed to strengthen pandemic preparedness and combat antimicrobial resistance, highlighting the importance of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), a host-derived, pan-viral biomarker that addresses key limitations of PCR-based diagnostics. Current methods for ddhC measurement rely on liquid ...

#4 [9.5] Structure-Guided Optimization of a LipL32-Targeting DNA Aptamer through Molecular Dynamics and Free-Energy Analysis

Abstract Accurate detection of leptospirosis requires high-affinity recognition of the conserved LipL32 biomarker. Although LipL32-targeting DNA aptamers have been identified through systematic evolution of ligands by exponential enrichment (SELEX), the molecular basis of their target recognition remains unclear, limiting rational post-SELEX opt...

#5 [9.2] Recognition–decision–execution: a new design principle for intelligent antimicrobial systems

The continued rise of antimicrobial resistance highlights fundamental limitations of prevailing antibacterial strategies, which remain largely dominated by continuous, non-directed killing. Although combination therapies and multifunctional materials are frequently described as synergistic, many reported effects primarily reflect pharmacokinetic...

#6 [6.3] Comparative antiviral properties of GO and rGO nanocomposites modified with AuNPs and ZnO against dengue virus type 3

#7 [6.0] Programmable design of functional RNAs through multimodal generative learning

RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative model that learns a conditionable design grammar from RNA sequences, experimental structural probing profiles, and functional annotations. Beyond setti...

#8 [5.3] Chromogenic and FRET peptide substrates, quantum‐dot peptide conjugates and electrochemical peptide interfaces: A 25‐year journey from combinatorial chemistry to clinical readouts—A viewpoint

This Viewpoint synthesises 25 years of work from a single laboratory on activity‐based protease sensing and offers a critical appraisal of where each of the three resulting platforms stands today. The activity of proteolytic enzymes—rather than their abundance—determines the outcome of inflammation, tumour progression, viral entry and barrier dy...

Methodology