Aptamer 学术简报 — therapeutic — 2026-10-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 67 篇命中（aptamer 池 207 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.4] A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples.

To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of two zwitterionic monomers [...

#2 [15.2] Beyond Static Architectures: Responsive Tetrahedral Framework Nucleic Acids for Precise Theranostics.

Precise theranostics requires spatiotemporal control and high specificity to adapt to complex physiological microenvironments. Tetrahedral framework nucleic acids (tFNA), classic 3D DNA nanostructures, offer distinct advantages such as atomic-level structural precision, intrinsic programmability, and excellent biocompatibility. While traditional...

#3 [15.2] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

#4 [13.3] G4All: a database of experimentally confirmed G-quadruplex-forming sequences.

G-quadruplexes (G4s) are non-canonical nucleic acid structures with critical roles in gene regulation, genomic stability, and disease, making them prime targets for therapeutic and biotechnological applications. However, the absence of a curated, centralized, experimentally validated repository of short (mostly synthetic) G4-forming sequences, p...

#5 [13.2] Aptamer-Functionalized Pro-Photosensitizers for Targeted Elimination of Drug-Resistant Bacterial Biofilm Infection by Sequentially Activated Photodynamic-Antibiotic Therapy.

Drug-resistant bacterial infections seriously threaten public health, and the formation of a biofilm barrier plays an important role. Drug-resistant biofilms are difficult to remove because the penetration and specificity of traditional antimicrobial drugs are poor, and the microenvironment in the inner layer of biofilms is hypoxic. Herein, we d...

#6 [13.0] Engineering aptamer-based therapeutics for precision cancer immunotherapy: from molecular targeting to clinical applications

Although cancer immunotherapy has revolutionized cancer therapy, the clinical efficacy of this approach is restricted due to tumor heterogeneity, immune escape, therapeutic resistance, poor tumor penetration, and toxic side effects. Short single-stranded DNA or RNA oligonucleotides, termed aptamers, have high affinity for a given target, low imm...

#7 [12.8] Re-entering the cell: Is the intracellular space the true therapeutic niche for aptamers?

First conceptualized in the early 1990s by the Tuerk, Gold, and Szostak laboratories, nucleic acid aptamers—often dubbed “chemical antibodies”—were envisioned as a disruptive class of targeted therapeutics.1 Selected via systemic evolution of ligands by exponential enrichment (SELEX), an iterative in vitro process that sorts massive combinatoria...

#8 [12.3] Electrochemical Aptamer-Based Sensors Supporting Real-Time, Seconds-Resolved, Molecular Measurements in Awake, Behaving Rats.

The real-time, in vivo measurement of drugs, metabolites, and biomarkers in awake animals could enable unprecedented insights into metabolic regulation, pharmacokinetics, pharmacodynamics, and behavioral response. In pursuit of this vision, here we demonstrate a subcutaneous electrochemical aptamer-based (EAB) sensor architecture that (i) suppor...

#9 [12.1] Bioanalytical Detection of Parasitic Infections: Advances in Immunological Assays and Biosensor-Based Diagnostics.

Parasitic diseases continue to be an important public health problem and impact over one billion people worldwide; therefore, there is an urgent need for new, high-performance diagnostic methods that are sensitive, rapid, and accessible. Conventional parasitological and laboratory-based diagnosis can be time-consuming, require specialized equipm...

#10 [11.7] PK-Tracker: A Real-Time Bedside Device for Continuous Therapeutic Drug Monitoring.

Medical procedures often require the administration of drugs, whose dosing is typically guided by pharmacodynamic responses rather than direct measurement of concentrations. This limitation largely arises from traditional monitoring procedures that rely on repeated venous sampling followed by laboratory analyses using cumbersome and costly instr...

Methodology