Aptamer 学术简报 — therapeutic — 2026-10-17

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 52 篇命中（aptamer 池 141 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.5] Beyond SELEX: AI-driven aptamers from sequence to structure to function.

Conventional aptamer discovery by systematic evolution of ligands by exponential enrichment (SELEX) is often constrained by limited library capacity, PCR bias, and multi-round screening. The recent convergence of artificial intelligence with aptamer development is driving a paradigm shift from empirical screening toward rational, data-driven des...

#2 [13.8] Tetrahedral framework nucleic acids loaded with resveratrol and TNF-α aptamer for the treatment of peripheral joint lesions in ankylosing spondylitis

Abstract Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease affecting the spine, sacroiliac and peripheral joints, with TNF-α as a core pro-inflammatory cytokine. Macrophages, as major TNF-α producers, form a positive feedback loop that amplifies local inflammatory responses. The use of clinical TNF inhibitors such as inflixi...

#3 [13.7] Receptor Dimerization-Engineering Hydrogel to On-Demand Regulate Cellular Behaviors.

Manipulation of cell-surface receptor dimerization plays a critical role in modulating cellular behaviors, yet the controllable regulation and dimerization efficiency of receptors remain challenging. Here, a dynamic bispecific aptamer within triglycerol monostearate (TGMS) nanoparticles hydrogel termed REMEDY (receptor dimerization-engineering d...

#4 [13.3] Smart Oral Capsule with a Closed-Loop Sense-Decide-Act Strategy for Colitis Therapy.

Current treatments for inflammatory bowel disease (IBD) lack real-time inflammatory monitoring and lesion-specific drug delivery, resulting in poor efficacy and systemic toxicity. To address this, we present a smart oral capsule that operates a closed-loop "sense-decide-act" strategy entirely autonomously-sensing and drug release are driven by c...

#5 [13.2] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells ...

#6 [13.0] Copper-Peptide Assemblies with Self-Driven Signal Release for Electrochemical Analysis of Exosomes

Abstract Multifunctional peptides have garnered considerable attention owing to their excellent biocompatibility and unique physicochemical properties. Herein, we report an electrochemical method for the sensitive detection of exosomes based on copper-peptide assemblies with a self-driven signal release approach. In the design, an engineered his...

#7 [12.6] Recognition–decision–execution: a new design principle for intelligent antimicrobial systems

The continued rise of antimicrobial resistance highlights fundamental limitations of prevailing antibacterial strategies, which remain largely dominated by continuous, non-directed killing. Although combination therapies and multifunctional materials are frequently described as synergistic, many reported effects primarily reflect pharmacokinetic...

#8 [12.5] Chemical Reaction Driven Photoelectrochemical and Colorimetric Dual‐Mode Biosensing: A Label‐Free Strategy for Adenosine Deaminase Detection Based on IDIC‐4Cl

ABSTRACT Photoelectrochemical (PEC) sensing offers high sensitivity and rapid response, but its broader bioanalytical utility is constrained by the lack of intrinsic molecular recognition in most photoactive materials. Here, we present the non‐fullerene acceptor (NFA) IDIC‐4Cl as a chemically addressable photoactive material that integrates chem...

#9 [12.0] Fluorescent aptamer sensing of clenbuterol and salbutamol in artificial urine and construction of a proof-of-concept screening model.

A proof-of-concept differential dual-modal aptamer array was developed for clenbuterol (CLB) and salbutamol (SAL) screening in artificial urine. A CLB-selective aptamer and AP-Ago, a broad β2-agonist aptamer, were coupled to graphene-oxide fluorescence resonance energy transfer and to methylene-blue/ferrocene-labelled gold electrodes. Their four...

#10 [11.9] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

Methodology