Aptamer 学术简报 — therapeutic — 2026-10-25

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 63 篇命中（aptamer 池 177 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.7] A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples.

To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of two zwitterionic monomers [...

#2 [14.3] G4All: a database of experimentally confirmed G-quadruplex-forming sequences.

G-quadruplexes (G4s) are non-canonical nucleic acid structures with critical roles in gene regulation, genomic stability, and disease, making them prime targets for therapeutic and biotechnological applications. However, the absence of a curated, centralized, experimentally validated repository of short (mostly synthetic) G4-forming sequences, p...

#3 [14.2] Aptamer-Functionalized Pro-Photosensitizers for Targeted Elimination of Drug-Resistant Bacterial Biofilm Infection by Sequentially Activated Photodynamic-Antibiotic Therapy.

Drug-resistant bacterial infections seriously threaten public health, and the formation of a biofilm barrier plays an important role. Drug-resistant biofilms are difficult to remove because the penetration and specificity of traditional antimicrobial drugs are poor, and the microenvironment in the inner layer of biofilms is hypoxic. Herein, we d...

#4 [13.8] Re-entering the cell: Is the intracellular space the true therapeutic niche for aptamers?

First conceptualized in the early 1990s by the Tuerk, Gold, and Szostak laboratories, nucleic acid aptamers—often dubbed “chemical antibodies”—were envisioned as a disruptive class of targeted therapeutics.1 Selected via systemic evolution of ligands by exponential enrichment (SELEX), an iterative in vitro process that sorts massive combinatoria...

#5 [13.3] Electrochemical Aptamer-Based Sensors Supporting Real-Time, Seconds-Resolved, Molecular Measurements in Awake, Behaving Rats.

The real-time, in vivo measurement of drugs, metabolites, and biomarkers in awake animals could enable unprecedented insights into metabolic regulation, pharmacokinetics, pharmacodynamics, and behavioral response. In pursuit of this vision, here we demonstrate a subcutaneous electrochemical aptamer-based (EAB) sensor architecture that (i) suppor...

#6 [12.7] PK-Tracker: A Real-Time Bedside Device for Continuous Therapeutic Drug Monitoring.

Medical procedures often require the administration of drugs, whose dosing is typically guided by pharmacodynamic responses rather than direct measurement of concentrations. This limitation largely arises from traditional monitoring procedures that rely on repeated venous sampling followed by laboratory analyses using cumbersome and costly instr...

#7 [12.6] Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targeting aptamer SL1 with early, recycling, and late endosomes following endocyt...

#8 [11.9] Beyond SELEX: AI-driven aptamers from sequence to structure to function.

Conventional aptamer discovery by systematic evolution of ligands by exponential enrichment (SELEX) is often constrained by limited library capacity, PCR bias, and multi-round screening. The recent convergence of artificial intelligence with aptamer development is driving a paradigm shift from empirical screening toward rational, data-driven des...

#9 [11.6] Nano-enabled approaches in virology: emerging strategies for rapid detection, antiviral therapy, and biomimetic innovation

Global health continues to be impacted by viral diseases, and this poses a need for timely diagnosis, potent antiviral treatment, and flexible prevention. To tackle these problems, nanotechnology has become an incredibly flexible tool for viral detection, therapeutic delivery, vaccination and biomimetic material design. Recent developments in th...

#10 [11.5] Dual-signal fluorescent-colorimetric aptasensor for tobramycin detection in milk based on fluorescent magnetic nanoparticles and AuNPs.

Tobramycin (TOB) is an aminoglycoside antibiotic employed in human and veterinary medicine whose residues in food raise safety concerns. To resolve this issue, we developed a dual-mode aptamer-based sensor for sensitive TOB detection via fluorescence and colorimetric signals. The platform utilizes fluorescent magnetic nanoparticles (FMNs) conjug...

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