Aptamer 学术简报 — therapeutic — 2026-10-21

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 61 篇命中（aptamer 池 175 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.0] PK-Tracker: A Real-Time Bedside Device for Continuous Therapeutic Drug Monitoring.

Medical procedures often require the administration of drugs, whose dosing is typically guided by pharmacodynamic responses rather than direct measurement of concentrations. This limitation largely arises from traditional monitoring procedures that rely on repeated venous sampling followed by laboratory analyses using cumbersome and costly instr...

#2 [13.9] Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targeting aptamer SL1 with early, recycling, and late endosomes following endocyt...

#3 [13.2] Beyond SELEX: AI-driven aptamers from sequence to structure to function.

Conventional aptamer discovery by systematic evolution of ligands by exponential enrichment (SELEX) is often constrained by limited library capacity, PCR bias, and multi-round screening. The recent convergence of artificial intelligence with aptamer development is driving a paradigm shift from empirical screening toward rational, data-driven des...

#4 [12.8] Dual-signal fluorescent-colorimetric aptasensor for tobramycin detection in milk based on fluorescent magnetic nanoparticles and AuNPs.

Tobramycin (TOB) is an aminoglycoside antibiotic employed in human and veterinary medicine whose residues in food raise safety concerns. To resolve this issue, we developed a dual-mode aptamer-based sensor for sensitive TOB detection via fluorescence and colorimetric signals. The platform utilizes fluorescent magnetic nanoparticles (FMNs) conjug...

#5 [12.7] An Easy Oligonucleotide Platform for Rapid, Post-Isolation EV Modification: Dual-Function Uptake Control and Enhanced Targeting.

Extracellular vesicles (EVs) hold immense therapeutic potential, yet their clinical translation is hindered by nonspecific cellular uptake and the complexity and cost of surface engineering. Here, we present the EZON (Easy OligoNucleotide) EV modification platform, a cost-effective, post-isolation modification system that addresses both limitati...

#6 [12.7] A Dual-Lock Activatable Fluorescent Probe Leveraging Tumor Metabolic and Enzymatic Features for Precision Imaging

Abstract Achieving highly sensitive and precise detection and imaging of cancer cells within the body is crucial for providing pathological information support in disease diagnosis and treatment. However, due to the existence of factors such as non-specific activation in local areas, membrane barriers, and the complexity of the intracellular env...

#7 [12.5] Tetrahedral framework nucleic acids loaded with resveratrol and TNF-α aptamer for the treatment of peripheral joint lesions in ankylosing spondylitis

Abstract Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease affecting the spine, sacroiliac and peripheral joints, with TNF-α as a core pro-inflammatory cytokine. Macrophages, as major TNF-α producers, form a positive feedback loop that amplifies local inflammatory responses. The use of clinical TNF inhibitors such as inflixi...

#8 [12.3] Receptor Dimerization-Engineering Hydrogel to On-Demand Regulate Cellular Behaviors.

Manipulation of cell-surface receptor dimerization plays a critical role in modulating cellular behaviors, yet the controllable regulation and dimerization efficiency of receptors remain challenging. Here, a dynamic bispecific aptamer within triglycerol monostearate (TGMS) nanoparticles hydrogel termed REMEDY (receptor dimerization-engineering d...

#9 [12.3] Modular Cell-Surface-to-Solution CRISPR-Cas12a Platform for Wash-Free Quantification of Cell−Surface Proteins on Living Cells

Abstract Cell−surface proteins are important biomarkers for cell phenotyping, disease diagnosis, therapeutic evaluation, and drug screening. However, their quantitative analysis on intact living cells remains challenging because conventional methods often require cell lysis, fixation, repeated washing, extensive sample processing, or bulky instr...

#10 [12.0] Smart Oral Capsule with a Closed-Loop Sense-Decide-Act Strategy for Colitis Therapy.

Current treatments for inflammatory bowel disease (IBD) lack real-time inflammatory monitoring and lesion-specific drug delivery, resulting in poor efficacy and systemic toxicity. To address this, we present a smart oral capsule that operates a closed-loop "sense-decide-act" strategy entirely autonomously-sensing and drug release are driven by c...

Methodology