Aptamer 学术简报 — therapeutic — 2026-11-02

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 72 篇命中（aptamer 池 210 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.4] Aptamer-mediated multivalent endogenous ADAR1 recruitment for highly efficient RNA editing.

Adenosine-to-inosine RNA editing mediated by endogenous ADAR enzymes represents a promising therapeutic strategy because it can correct mutations at the transcript level without inducing permanent changes to the genome. However, existing systems face challenges, particularly the limited editing efficiency, which limits their practical applicatio...

#2 [15.0] A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples.

To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of two zwitterionic monomers [...

#3 [13.8] Expanding synthetic lethality through computationally designed aptamers

Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic RNAs, and direct modulation...

#4 [13.6] Amplifying the invisible: Liquid crystal-hydrogel microcavities decode trace Hg ions and aflatoxin B1.

Chinese herbal medicines (CHMs) have been applied to the prevention and treatment of numerous diseases. Ensuring the safety and pharmacological efficacy of CHMs demands precise detection of trace heavy metal ions and toxins, especially Hg and aflatoxin B1 (AFB1). However, due to subtle chemical signals, current technologies still make it challen...

#5 [13.6] Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

ABSTRACT N1‐methylpseudouridine ( m Ψ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional non‐coding RNAs has only been scarc...

#6 [13.6] Adaptation of a Fluorogenic RNA to N1-Methylpseudouridine Nucleoside Chemistry.

N1-methylpseudouridine (mΨ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional non-coding RNAs has only been scarcely studied...

#7 [13.5] Beyond Static Architectures: Responsive Tetrahedral Framework Nucleic Acids for Precise Theranostics.

Precise theranostics requires spatiotemporal control and high specificity to adapt to complex physiological microenvironments. Tetrahedral framework nucleic acids (tFNA), classic 3D DNA nanostructures, offer distinct advantages such as atomic-level structural precision, intrinsic programmability, and excellent biocompatibility. While traditional...

#8 [13.5] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

#9 [12.8] A pH/miR-21 dual-responsive multifunctional DNA tetrahedron for targeted tumor imaging and synergistic chemo-gene therapy.

Small interfering RNA (siRNA) presents promising prospects as a therapeutic agent; its clinical application is constrained by challenges such as inefficient delivery and off-target effects. This study developed a multifunctional DNA Tetrahedron (MDT) platform for synergistic delivery of siRNA and the chemotherapeutic agent doxorubicin (DOX) to o...

#10 [12.3] Exosome‐Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi–Chemo Therapy Through Cholesterol‐Free, Tumor‐Preferential Delivery

Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are developed to embed three exosoma...

Methodology