Aptamer 学术简报 — therapeutic — 2026-11-06

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 70 篇命中（aptamer 池 209 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.1] Aptamer-mediated multivalent endogenous ADAR1 recruitment for highly efficient RNA editing.

Adenosine-to-inosine RNA editing mediated by endogenous ADAR enzymes represents a promising therapeutic strategy because it can correct mutations at the transcript level without inducing permanent changes to the genome. However, existing systems face challenges, particularly the limited editing efficiency, which limits their practical applicatio...

#2 [13.0] From recognition to delivery: nucleic acid aptamers in miRNA-related diagnosis and therapy of hepatocellular carcinoma

Hepatocellular carcinoma (HCC), the most common primary malignant liver tumour, remains a major clinical challenge because of its low early diagnosis rate and high post-treatment recurrence. MicroRNAs (miRNAs) play key regulatory roles in HCC development and progression and are potential liquid biopsy biomarkers and therapeutic targets. However,...

#3 [13.0] Aptamer-modified magnetic chitosan nanocomposites for rapid and targeted decontamination of aflatoxin B(1) in medicine-food homologous decoctions.

A novel aptamer-functionalized core-shell magnetic chitosan adsorbent (Fe₃O₄@CS@apt) was developed for the selective removal of a flatoxin B1 (AFB1). The material was synthesized via emulsification cross-linking followed by EDC/sulfo-NHS-mediated aptamer conjugation. Characterization confirmed the core-shell structure and superparamagnetic prope...

#4 [12.5] Expanding synthetic lethality through computationally designed aptamers

Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic RNAs, and direct modulation...

#5 [12.3] NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis.

Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform, SNs/FTC@Apt-P (SFTCP), constructed by in...

#6 [12.3] Amplifying the invisible: Liquid crystal-hydrogel microcavities decode trace Hg ions and aflatoxin B1.

Chinese herbal medicines (CHMs) have been applied to the prevention and treatment of numerous diseases. Ensuring the safety and pharmacological efficacy of CHMs demands precise detection of trace heavy metal ions and toxins, especially Hg and aflatoxin B1 (AFB1). However, due to subtle chemical signals, current technologies still make it challen...

#7 [12.2] Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

ABSTRACT N1‐methylpseudouridine ( m Ψ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional non‐coding RNAs has only been scarc...

#8 [12.2] Adaptation of a Fluorogenic RNA to N1-Methylpseudouridine Nucleoside Chemistry.

N1-methylpseudouridine (mΨ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional non-coding RNAs has only been scarcely studied...

#9 [12.2] Beyond Static Architectures: Responsive Tetrahedral Framework Nucleic Acids for Precise Theranostics.

Precise theranostics requires spatiotemporal control and high specificity to adapt to complex physiological microenvironments. Tetrahedral framework nucleic acids (tFNA), classic 3D DNA nanostructures, offer distinct advantages such as atomic-level structural precision, intrinsic programmability, and excellent biocompatibility. While traditional...

#10 [12.2] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

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