Aptamer 学术简报 — 2026-10-19

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 170 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.4] Triple quenching strategy-based highly sensitive electrochemiluminescence sensor for perfluorooctanoic acid.

Quenching-based electrochemiluminescence (ECL) sensing boasts prominent advantages for trace analysis, while single-mechanism systems have inherent flaws, making the development of efficient synergistic quenching strategies of great practical significance for ultra-trace perfluorooctanoic acid (PFOA) detection. In this work, a zinc-coordinated p...

#2 [20.2] A dual-aptamer colorimetric sensor based on Cu-MOF@PtPdNPs for the highly sensitive detection of MUC1.

The abnormally high expression of MUC1 in various malignant tumors makes it a crucial biomarker for early cancer diagnosis. This study synthesized a Cu-MOF@PtPdNPs nanocomposite exhibiting robust peroxidase-like activity via an in-situ reduction method. By integrating this nanomaterial with a dual-aptamer recognition sandwich strategy, an effici...

#3 [14.6] Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targeting aptamer SL1 with early, recycling, and late endosomes following endocyt...

#4 [14.0] Highly-Time-Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals.

Current theories regarding tryptophan's homeostatic regulation, which are derived from in vitro, post-mortem, and cell-culture studies, lack any direct evidence supporting their occurrence in living subjects. In response, here we have used 20 s resolution, multi-hour plasma measurements to confirm, for the first time, that the cooperativity and ...

#5 [13.9] Integrated Antigen–DNA Co‐Detection Using Digital Microfluidics for Improving Diagnostic Accuracy in POCT Analysis

ABSTRACT Simultaneous detection of protein and nucleic acid (NA) provides complementary information essential for accurate analysis of complex samples. Conventional approaches for the analysis of protein and NA typically rely on separate workflows and instruments, limiting the reliability of point‐of‐care testing. Here, we present a digital micr...

#6 [13.9] Integrated Antigen–DNA Co‐Detection Using Digital Microfluidics for Improving Diagnostic Accuracy in POCT Analysis

Simultaneous detection of protein and nucleic acid (NA) provides complementary information essential for accurate analysis of complex samples. Conventional approaches for the analysis of protein and NA typically rely on separate workflows and instruments, limiting the reliability of point-of-care testing. Here, we present a digital microfluidics...

#7 [13.9] Beyond SELEX: AI-driven aptamers from sequence to structure to function.

Conventional aptamer discovery by systematic evolution of ligands by exponential enrichment (SELEX) is often constrained by limited library capacity, PCR bias, and multi-round screening. The recent convergence of artificial intelligence with aptamer development is driving a paradigm shift from empirical screening toward rational, data-driven des...

#8 [13.5] Dual-signal fluorescent-colorimetric aptasensor for tobramycin detection in milk based on fluorescent magnetic nanoparticles and AuNPs.

Tobramycin (TOB) is an aminoglycoside antibiotic employed in human and veterinary medicine whose residues in food raise safety concerns. To resolve this issue, we developed a dual-mode aptamer-based sensor for sensitive TOB detection via fluorescence and colorimetric signals. The platform utilizes fluorescent magnetic nanoparticles (FMNs) conjug...

#9 [13.3] A Dual-Lock Activatable Fluorescent Probe Leveraging Tumor Metabolic and Enzymatic Features for Precision Imaging

Abstract Achieving highly sensitive and precise detection and imaging of cancer cells within the body is crucial for providing pathological information support in disease diagnosis and treatment. However, due to the existence of factors such as non-specific activation in local areas, membrane barriers, and the complexity of the intracellular env...

#10 [13.3] A machine learning-optimized bivalent aptasensor based on exonuclease Ⅰ amplification for trace okadaic acid detection

Consumption of okadaic acid (OA)-contaminated seafood endangers human health, highlighting the need for sensitive quantitative detection. Herein, a convenient and highly sensitive bivalent aptasensor was developed for fluorescence detection of OA in aquatic products. The aptasensor was constructed using a bivalent aptamer (B-Apt) as the recognit...

Methodology