Aptamer 学术简报 — 2026-10-08

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 207 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [22.5] Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection.

The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the development of a high-performance ...

#2 [20.1] An ultrasensitive colorimetric platform for tetracycline based on the aptamer tailoring strategy and synergistic signal amplification of Au@Ce MOF.

In this study, a rapid Au@Ce MOF-Apt functionalized three-dimensional (3D) paper platform was constructed for the detection of TC in milk. To obtain a high-affinity aptamer (Apt), based on truncation and base mutation, resulting in high-affinity G-rich sequence aptamer (Apt-M24) (27 nt, -10.4 kcal/mol). Subsequently, the Apt-M24 was efficiently ...

#3 [20.1] A bioelectrochemical aptamer sensor using vanadium-porphyrinic metal-organic framework for noninvasive hydrocortisone monitoring in sweat.

Hydrocortisone (HC) is a vital steroid hormone secreted by the adrenal cortex that regulates how the body responds to stress, the immune system and metabolism. The primary objective of this study is the fabrication of an electrochemical aptamer sensor founded on a vanadium-porphyrin metal-organic framework (V-PMOF) to detect HC. V2CTx MXene acts...

#4 [17.8] High-sensitivity simultaneous discrimination and detection of structurally similar adenosine phosphates via DNA aptamer conformational changes in α-hemolysin nanopore.

Adenosine phosphates (ATP, ADP, and AMP) play critical roles in cellular processes, yet their simultaneous detection remains challenging due to high structural similarity. To overcome this limitation, we developed a nanopore-aptamer sensing platform capable of tracking single-molecule binding dynamics in real time. This method leverages the spec...

#5 [17.8] Multiplexed electrochemical aptasensor on a nanoporous electrode: towards sensitive and anti-fouling detection of procaine, ATP and adenosine in biofluids.

This study presents a green and simple one-step electrochemical strategy for preparing nanoporous gold electrodes. The method involves anodizing the gold electrode by linear sweep voltammetry (LSV) in an aqueous solution of l-ascorbic acid (AA) and hydrochloric acid (HCl). The gold electrodes were etched in solution by hydrochloric acid to gener...

#6 [17.6] Online aptamer-based solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry for the determination of Alzheimer's disease biomarkers.

BACKGROUND: Reliable quantification of amyloid-β (Aβ) peptides in biological fluids is of major clinical and research interest in Alzheimer disease context. Conventional offline extraction approaches often involve labor-intensive manual steps and high solvent consumption, limiting throughput routine applications, reproducibility, and sustainabil...

#7 [14.2] Acid-Activatable Rolling Circle Replication-Based Nucleic Acid Nano-Prodrug for Combined Gene Therapy of Pancreatic Cancer.

Nucleic acid-based gene therapeutics hold great potential for precisely treating pancreatic ductal adenocarcinoma (PDAC), yet their clinical translation remains challenged by the lack of efficient delivery platforms capable of simultaneously minimizing payload leakage, intrinsic toxicity, and immunogenicity. Herein, we report an acid-activatable...

#8 [14.0] Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients.

Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug-induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (ECL) aptasensor for the detection of cardiac troponin I (cTnI) based on a two...

#9 [14.0] Improving aptamer binding affinity for HN protein of newcastle disease virus: molecular dynamics simulations and MM/GBSA calculations studies.

Aptamers, as single-stranded DNA (ssDNA) or RNA oligonucleotides, are pivotal in biosensing due to their high affinity. However, excessive lengths of these nucleic acid probes can impair their binding affinity and target recognition efficiency. Traditional optimization methods, such as static structural modeling, fail to capture the dynamic inte...

#10 [14.0] Label-free impedimetric aptasensor based on PEDOT‑gold nanocomposite for the selective detection of Escherichia coli O157:H7.

In this study, a label-free impedimetric aptasensor employing a glassy carbon electrode (GCE) modified with a nanocomposite of poly (3,4-ethylenedioxythiophene) and gold nanoparticles was developed. Following surface preparation, specific aptamer strands were covalently immobilized onto the electrode to enable the selective recognition of Escher...

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